LRRK2 and Parkinson disease: This hypothesis is also supported by many studies reporting mitochondrial dysfunction in various animal models of G2019S-LRRK2 PD, in postmortem human tissues from LRRK2-PD patients (Mortiboys et al., 2010; Cooper et al., 2012; Sanders et al., 2014; Yue et al., 2015) and in different patient-derived cell models (Niu et al., 2012; Wang et al., 2012; Cherra et al., 2013; Su and Qi, 2013).