In addition, the target genes of the mitochondrial master transcriptional regulator PGC1α have been reported to be under expressed in PD, together with strong evidences of increased oxidative stress and reduced autophagic function that may be finally responsible for defective mitochondrial and protein depot (Schapira and Gegg, 2011; Nixon, 2013; Siddiqui et al., 2015). This evidence concerns the gene PPARGC1A and Parkinson disease.