Additional studies in PRKN-PD fibroblasts have reported alterations in the protein expression and lipidome profiles (Lippolis et al., 2015; Lobasso et al., 2017) as well as cytoskeleton alterations such as microtubule destabilization (Cartelli et al., 2012; Vergara et al., 2015). This evidence concerns the gene PRKN and Parkinson disease.