PRKN and Parkinson disease: Interestingly, they also examined an unusual homozygous PRKN mutation carrier who did not develop clinical PD by her eight decade and found preserved mitochondrial function due to the induction of a PINK1/Parkin-independent mitophagy mediated by Nix, which is a selective autophagic receptor located on the OMM (Koentjoro et al., 2017).