Although S1R KO mice do not develop an overt ALS phenotype (Langa et al., 2003), they have deficits in locomotion and motor performance (Mavlyutov et al., 2010) related to muscle weakness, axonal degeneration, and motor neuron loss (Bernard-Marissal et al., 2015). This evidence concerns the gene TMBIM4 and amyotrophic lateral sclerosis.