The novel positive S1R modulator (±)-2-(3-chlorophenyl)-3,3,5,5-tetramethyl-2-oxo-oxazaphosphinane (OZP002) (Gundlach et al., 1986; Maurice et al., 2006a; Tsai et al., 2009) was also neuroprotective in pharmacological and genetic models of AD. The gene discussed is TMBIM4; the disease is Alzheimer disease.