TMBIM4 and memory impairment: For example, pharmacological inhibition of S1R leads to mushroom spine loss in hippocampal cultures (Ryskamp et al., 2019) and this could be related to memory impairments from the anti-psychotic drug and S1R antagonist haloperidol (KD for S1R ∼3 nM) (Abdel-Salam et al., 2012).