Treatment of SOD1G93A mice with the S1R agonist pridopidine improves axonal transport (e.g., of BDNF, GDNF, and mitochondria) and BDNF secretion while attenuating atrophy of neuromuscular junctions, muscle fibers and motor neurons (Ionescu et al., 2019) (pharmacological properties summarized in HD section). Here, TMBIM4 is linked to Huntington disease.