S1R agonists promote neurogenesis in the hippocampus (Moriguchi et al., 2013) and they may mitigate memory impairment because they can stabilize mature, mushroom spines (Ryskamp et al., 2019), which serve as sites of robust synaptic connections encoding lasting information (Bourne and Harris, 2007; Hayashi-Takagi et al., 2015). Here, TMBIM4 is linked to memory impairment.