Most of Lynch syndrome-related colorectal cancers developed through the MSI pathway which may affect genes that control cell growth (transforming growth factor [TGF] beta and insulin-like growth factor [sIGF] receptors), regulate apoptotic cell death (Caspase 5, Bax), and some of the DNA MMR genes themselves (MSH3, MSH6). The gene discussed is MSH6; the disease is colorectal cancer.