REV1 and cancer: We also found two DNA repair genes, Rev1 and Cdc5l, with variants that result in amino acid substitution: chr1:38,088,013 T > C, chr1:38088020 C > G (K > E and K > N amino acid changes) in Rev1; and chr17:45,407,947 G > A (causing a T > M amino acid change) in Cdc5l. The remaining genes that possessed detrimental variants were involved with cell cycle regulation or cancer progression.