To better validate the capability of the nanotransporter to curb localized infection, we monitored the change of two major sepsis-associated biochemical markers (procalcitonin (PCT), c-reactive protein (CRP)) in the blood of the MRSA-infected mice after treatment with PBS, NIR-irradiated IMP/IR780@TRN, and 3× IMP (Fig. 7a, b). Here, CRP is linked to Sepsis.