The molecular characteristics of invasive breast cancer (TNBC, HER2-positive, ER-positive) in the breast cancer cell lines according to their OR gene upregulation were not similar to those observed in breast carcinoma patients, specifically between cell group I and patient sub-population I with OR2B6 upregulation, and between cell group III and patient sub-population III with OR2W3 upregulation. The gene discussed is ESR1; the disease is breast cancer.