These included novel associations of variants at COL5A1 with cerebrovascular disease (P = 4.6 × 10−4), GALNT16 with angina (P = 9.3 × 10−4), MBOAT7 with venous thromboembolism (P = 1.3 × 10−3), GLTPD2 with atherosclerosis (P = 5.3 × 10−4) and SPTLC3 with intracerebral haemorrhage (P = 1.0 × 10−3) (Fig. 5). The gene discussed is SPTLC3; the disease is angina pectoris.