EGFR and colorectal carcinoma: Another research focused on triple treatment with regorafenib plus sildenafil (a phosphodiesterase 5 inhibitor) and neratinib (an ERBB1/2/4 inhibitor) found a more than additive inhibitory effect on CRC cells growth in vitro and in vivo, enhancing harmful autophagosome formation, death receptor signaling activation and mitochondrial and lysosomal dysfunction.