Furthermore, ARID4B promoter-driven luciferase reporter gene assays showed that knockdown of PTEN activated the ARID4B promoter in the PTEN-intact prostate cancer cell line DU145 and cervical cancer cell line HeLa (Fig. 5f and Supplementary Fig. 10b), whereas overexpression of PTEN suppressed the ARID4B promoter activity (Fig. 5g). The gene discussed is PTEN; the disease is prostate cancer.