ARID4B and Familial prostate cancer: In contrast, tumor development in prostates of most of the 5-month-old PtenPC−/−Arid4bPC−/− mice was arrested at the normal, hyperplastic, or low-grade PIN stages (Fig. 4b, c and Supplementary Fig. 7c), suggesting that ablation of ARID4B attenuated prostate cancer progression.