In addition, while knockdown of ARID4B decreased expression of p110α and p85β in the prostate cancer cell lines PC3, DU145, and LNCaP (Fig. 1d and Supplementary Fig. 3), knockdown of HDAC1 increased expression of p110α and p85β (Supplementary Fig. 12). Here, HDAC1 is linked to Familial prostate cancer.