While adult glioma is driven by oncogenic mutations in IDH1/2, serine/threonine-protein kinase B-raf (BRAF) or fibroblast growth factor receptor (FGFR), paediatric cases of DIPG are characterised by mutations in histone proteins as well as developmental signalling proteins [12,13]. Here, BRAF is linked to diffuse intrinsic pontine glioma.