In addition, compared to incretin-based therapies, including glucagon-like-peptide 1 (GLP-1) agonists and dipeptidyl peptidase 4 (DPP-4) inhibitors, SGLT2 inhibitors are associated with lower risks of all-cause and cardiovascular-specific mortality, and occurrence of heart failure and myocardial infarction [6]. This evidence concerns the gene GCG and heart failure.