SGLT2 inhibitors, in addition to glycemic controls, also have a positive effect on the cardiometabolic markers, such as body weight, blood pressure and uric acid [10, 11], and as a result there has been increasing use of SGLT2 inhibitors for the management of type 2 diabetes in clinical practice [12]. The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.