ACTA1 and cardiac hypertrophy: The increased cardiac output was accompanied by myocardial hypertrophy resembling other forms of physiological hypertrophy as it did not go along with the expression of fetal genes such as those encoding natriuretic peptide A and B as well as the cardiac myosin heavy chain (Myh7) or skeletal muscle α-actin (Acta1) (Nakamura and Sadoshima, 2018).