VTN and Alzheimer disease: Furthermore, microglia activation due to accumulation of Aβ has also been believed to participate in the pathogenesis of AD.22, 23, 24 Microglia activation could induce neuronal damage by producing proinflammatory cytokines, chemokines, complement proteins, and upon strong activation may release toxic‐free radicals.25, 26 Neuroinflammation was proposed closely linked to and may even precede the development of other neuropathological characteristics of AD.27