PROCR and cytomegalovirus infection: Like CD8+ T cells, recognition of CMV‐infected targets by Vδ2 negative γδ T cells is TCR‐dependent, although this occurs independent of MHC.56 The nature of the ligand(s) for Vδ2‐negative γδ T cells remains unknown but may include EPCR.21 However, EPCR expression is not upregulated by CMV infection and recognition of target cells by EPCR‐reactive clones requires costimulatory ligands.21