TP53 and neoplasm: This high frequency detection of the LTAg in tissue samples of cases compared with controls is very strong evidence of the real virus contribution in PCa development rather than detecting the viral gene itself by PCR [28] because the active viral replication will produce the LTAg in the prostate tissue cells which will then bind the tumor suppresser antigens e.g. P53 resulted in disruption of apoptotic mechanism of the cell which subsequently leads to uncontrolled proliferation of prostate epithelia [29].