CCNB1 and lung adenocarcinoma: In the genomic analysis of patients with lung adenocarcinoma (Fig. 1a) and squamous cell carcinoma (Supplementary Fig. S1), major types of NSCLC, PLK1 was highly expressed concomitantly with proliferation markers MKI67 and CCNB1. Mesenchymal markers such as SNAI1/2 and FN1 were also upregulated, partially similar with PLK1 expression in tumors of NSCLC patients (Fig. 1a and Supplementary Fig. S1).