Mutations in NRAS (mutated in 4 tumors), ERBB3 (mutated in 3 tumors), RET, AKT1, AR, ARAF, BARD1, CDKN2A, GATA2, IDH2 MRE11A, NTRK1, PALB2 and SMO genes (each of these mutated in 1 tumor) were exclusively found in the distal colon. This evidence concerns the gene SMO and neoplasm.