APC was the most affected gene, altered in 65 tumor samples (71.4%), followed by TP53 (51 cases, 56.0%), KRAS (48 cases, 52.7%), PIK3CA (14 cases, 15.4%) and FBXW7 (10 cases, 10.9%, Fig. 1). The gene discussed is KRAS; the disease is neoplasm.