Notably, pathways of peroxisome, fatty acid biosynthesis, fatty acid degradation, sulfur metabolism, nicotinate and nicotinamide metabolism, pyrimidine metabolism, pyruvate metabolism and metabolic pathways were found among the top 20 enriched pathways of all the three comparisons (Supplemental Datas S8 and S9), suggesting that the Foc TR4 greatly influenced these pathways in the early infection stages. The gene discussed is NR2C2; the disease is infection.