Depending on the cellular context and in particular, expression levels of inhibitors of this pathway, such as DcR1, DcR2, c-FLIP (cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein), cIAP1, cIAP2, Bcl-2 (B-cell lymphoma 2) or Mcl-1 (myeloid cell leukemia 1), to cite a few, this proteolytic cascade ultimately leads to apoptosis, and to the specific killing of tumor cells bearing TRAIL agonist death receptors (DRs). This evidence concerns the gene TNFRSF10D and neoplasm.