TNFRSF10B and neoplasm: By targeting this membrane-bound protein with the BsAb MCSP × DR5, the authors of this study have been able to demonstrate first that binding of MCSP × DR5 mainly occurs on MCSP + DR5 + cells, compared to MCSP − DR5 + cells, indicating that binding mainly occurs through MCSP, and second, that BsAb MCSP × DR5 is able to induce tumor cell death both in an ADCC-dependent and -independent manner, in vitro [212].