In a randomized study on 198 CBF-AML patients assigned to either a reinforced and a standard induction course followed by three high-dose cytarabine consolidation courses, cumulative incidence of relapse and relapse-free survival (RFS) at 36 months were 22% vs. 54% (p < 0.001) and 73% vs. 44% (p < 0.001) in patients who achieved 3-log MRD reduction versus the others [22]. The gene discussed is CEBPZ; the disease is acute myeloid leukemia.