Stable overexpression of the secreted Wingless-INT (Wnt) antagonists secreted frizzled-related proteins (sFRPs) increases the expression of epithelial markers, reduces invasiveness and simultaneously downregulates Snail Family Transcriptional Repressor 2 (SNAI2) and Twist-related protein 1 (TWIST1) in PC cells. Here, SNAI2 is linked to pachyonychia congenita.