Again, ERβ but not ERα promotes survival and migration in the CPEC cell line established from PC patients, as shown by using the specific ER agonists, 2,3-bis(4-Hydroxyphenyl)-propionitrile (DPN) and 4,4′,4′′-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (PPT) [45]. Here, ESR2 is linked to pachyonychia congenita.