Here, in this study, we elucidated that (i) NLGP significantly inhibits the immunosuppression of tumor MSCs and restores T cell effector functions like normal, (ii) NLGP reduces the IL-10 secretion by tumor MSCs, and finally, (iii) the decreased IL-10 secretion results in reduced phosphorylation of STAT3 leading to transcription of cystathionase gene in DCs. The gene discussed is STAT3; the disease is neoplasm.