ARG1 and schistosomiasis: Furthermore, Kevin et al. [25] reported that distinct subsets of M2 macrophages controlled inflammation and fibrosis in chronic schistosomiasis, that the Arg-1-expressing M2 population slowed the development of lethal fibrosis and that Lyz2hiIL-4Rα+ M2 macrophages mediated the down-regulation of granulomatous inflammation in schistosomiasis.