Notably, CAFs isolated from fresh HCC tumor tissues exhibit an MSC phenotype, which manifests as increased clonogenic capacity; expression of CD73, CD90, CD105, CD44, CD13, CD29, and CD166; lack of CD31, CD34, CD45, CD117, and HLA-DR expression; and multipotent differentiation, such as adipogenic, osteogenic, and pancreatic differentiation [54, 55]. The gene discussed is PECAM1; the disease is hepatocellular carcinoma.