Abbreviations: BMI: Body Mass Index; EPIC: European Prospective Investigation into Cancer and nutrition; ER: estrogen receptor; FDR: False Discovery Rate; HER2: Human epidermal growth factor receptor 2; IARC: International Agency for Research on Cancer; MHT: menopause hormone therapy; MS: Mass spectrometry; NMR: nuclear magnetic resonance; OR: odds ratio; PC: phosphatidylcholine; PR: progesterone receptor; SD: standard deviation; WC: waist circumference. The gene discussed is ESR1; the disease is cancer.