TGFB1 and medulloblastoma: In this study, we looked at the effects of TGF-β-rich medulloblastoma supernatant on DNR-transduced NK cells, and we demonstrated protection from impaired cytotoxicity similar to what other groups [21, 22, 30–32] have reported, maintenance of TGF-β RII receptor expression, and protection from CD16 downregulation (which may suggest maintenance of ADCC in an immune suppressive environment) in line with observations made by Keskin et al. [33].