Strategies to reprogram CAFs to re-normalize tumor stroma targeted the epigenetic machinery, or pathways involved in CAF activation, e.g., TGF-β-mediated Smad2/3 signaling, using the viTAMsin-D derivative or the bioactive lipid lipoxin A4 [248,249], providing encouraging growth suppression in preclinical models. This evidence concerns the gene TGFB1 and neoplasm.