TNF and chronic myelogenous leukemia, BCR-ABL1 positive: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and resveratrol were observed to stimulate autophagic cell death in breast epithelial cells and chronic myelogenous leukemia cells, respectively, via AMPK activation and the suppression of downstream mTOR signaling [36,37].