Fito et al. in 2014 conducted a sub-sample study of 930 subjects at high cardiovascular risk previously enrolled in the PREDIMED study to show how adhesion to TDM could reduce the levels of important biomarkers of HF with special attention to N-amino terminal fragment of the prohormone BNP (NT-proBNP) [223]. This evidence concerns the gene NPPB and hydrops fetalis.