Paniagua et al., with a prospective study including eleven offspring of patients with obesity and diabetes divided into three groups, each following three different dietary plans each lasting 28 days, showed how, when compared to consuming a diet that was rich in carbohydrates or saturated fats, the MUFA-enriched diet has positive effects on insulin-resistant subjects through an improvement of Homeostasis model assessment for insulin resistance (HOMA-IR), a substitute for insulin sensitivity and proinsulin levels. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.