CRP is known for being responsible for endothelial dysfunction and the way in which it exercises its role is to negatively alter the stability and the uncoupling of NO synthase mRNA, therefore CRP represents a ligand of Lectin-like oxidized LDL receptor-1 (LOX-1), taking part both in inflammation and oxidative stress, which are strongly related to the development and maintenance of hypertension [115,116]. The gene discussed is OLR1; the disease is endothelial dysfunction.