TNF and ulcerative colitis: Evaluated against an ulcerative colitis model on mice, the amentoflavone showed decreases in the mucosal injury by lowered colonic wet weight as well as vascular permeability and diminished lactate dehydrogenase (LDH) and myeloperoxidase (MPO) activity reflecting reduced leukocyte infiltration and reducing significantly the tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and IL-6 levels as well as the expression of iNOS and COX-2 [56].