A gain-of function study revealed that the hypertrophic effects of miR-23b-5p overexpression observed in the Ang-II- and TAC-induced cardiac hypertrophy models was mediated via targeting high-mobility group box 2 (HMGB2) [97], a nuclear protein that regulates gene transcription, DNA recombination and repair, cell replication, and autophagy [98]. Here, AGT is linked to cardiac hypertrophy.