PKC leads to the activation of transcription factors involved in cardiac hypertrophy through a mitogen-activated protein kinase (MAPK) cascade, whereas PLC signaling products—inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG)—activates the calcium signaling pathway and PKC, respectively [58,59,60]. This evidence concerns the gene PRRT2 and hypertrophy.