Osteoglycin-deficient mice exhibit a high rate of left ventricular rupture following MI which was ameliorated by adenoviral overexpression of osteoglycin, as bridges were formed between collagen fibrils with osteoglycin, forming non-enzymatic collagen cross-links that stabilize the collagen fibers in the infarct scar tissue [152]. Here, OGN is linked to myocardial infarction.