Taken together, the current study for the first time provides strong evidence that the inactivation of Yap and the activation of Hippo pathway components indicated that UA leads to the activation of the Hippo pathway, which might ultimately induce apoptosis and inhibit proliferation and invasion/metastasis of SNU484 and SNU638 cells and tumor growth in xenograft animals. Here, YAP1 is linked to neoplasm.