Therefore, UA-mediated apoptosis in gastric cancer cells appeared to be accompanied by a downregulation of YAP1 and the activation of Hippo pathway; thus, our results demonstrated a direct connection between apoptosis by UA treatment and activation of Hippo pathway, which suppressed the expression of YAP proteins, a downstream target gene of Hippo pathway in gastric cancer cells. This evidence concerns the gene YAP1 and gastric cancer.