ADORA2A and neoplasm: While our findings suggest that NK cells might induce a higher disease-free survival in GBM patients, correlation between the expression of ADORA2A and NT5E might infer immunosuppression due to adenosinergic signaling on immune cells including NK as well as other cells, leading to poorer overall survival and suggesting that a complex interplay of tumor microenvironment factors is likely to affect pathology of GBM.