Indeed, according to Katsuno et al., BMP signaling can strengthen that of TGFβ, through activating the protein arginine methyltransferase 1 (PRMT1), which in turn methylates SMAD6/7, thereby enabling SMAD1/3/5 activation, to finally promote EMT during fibrosis as well as maintain a stem-like phenotype of cancer cells in malignancies [79]. This evidence concerns the gene TGFB1 and cancer.