Interestingly, mice limited to food intake of 8 h a day during natural nocturnal times compared to mice fed an equivalent high fat diet ad libitum had improved catabolic and anabolic pathway function and circadian clock oscillation, which optimised nutrient utilisation and energy expenditure, thus preventing glucose intolerance, hyperinsulinemia, fatty liver, inflammation, and obesity [54]. Here, CLOCK is linked to obesity due to melanocortin 4 receptor deficiency.