AD is a neurodegenerative disorder featured by a chronic neuroinflammation (increased levels of IL-1β, TNF-α, COX-1, COX-2, 12-LOX, and 15-LOX) due to an anomalous activation of the microglia, especially in the area of the brain (usually, the frontal cortex and hippocampus) that shows a higher concentration of extracellular Aβ plaques and intracellular neurofibrillary tangles (NFTs) [65]. Here, ALOX15 is linked to Alzheimer disease.