Mardiros and coworkers reported the development of CARs containing a CD123 specific scFv in combination with a CD28 co-stimulatory domain: T lymphocytes obtained from AML patients were modified to express CD123 CARs and acquired the capacity to lyse autologous AML blasts in vivo in a xenogeneic model of AML [153]. Here, IL3RA is linked to acute myeloid leukemia.