Our data indicate that Vδ2 T-cells exert a potent NKG2D-mediated cytolytic function against ZIKV infected cells, opening questions on the role of Vδ2 T-cells in fighting ZIKV infection in other tissues, and whether the lack of Vδ2 T-cells expansion might be associated with disease complications. The gene discussed is KLRK1; the disease is Zika virus infectious disease.