Considering the complex role of PPAR-γ2, C/EBP-α and FOXO1 in adipogenesis and insulin resistance, we propose that their expression profile in VAT from non-obese individuals and low insulin (LIR-MO) and high insulin morbidly obese (HIR-MO) subjects might shed light on their possible association with obesity-related insulin resistance. The gene discussed is FOXO1; the disease is obesity due to melanocortin 4 receptor deficiency.