Indeed, brain injury following trauma or peri-traumatic ischemia increases the concentration of specific biomarkers, such as S100β protein, neuronal-specific enolase (NSE), ubiquitin C-terminal hydrolase-L1 (UCH-L1), and glial fibrillary acidic protein (GFAP) [45,46,47,48]. Here, ENO2 is linked to ischemia.