Alonso et al. [112] showed that forodesine in combination with dGuo induced a dose-dependent cell death in CLL cells, but the response was independent of deletions in 17p13 (TP53) and 11q22-q23 (ATM), genetic aberrations acquired in advanced disease and associated with drug resistance and short survival [115]. Here, TP53 is linked to B-cell chronic lymphocytic leukemia.