This was in a high degree of agreement with the elegant study by Vazquez et al., where in the GSE7553 dataset for RNA expression of primary and metastatic melanoma patients grouped as per high and low PGC1A levels, GHR was the 10th and MITF was the 19th most differentially upregulated gene in the PGC1A-high cluster [47]. The gene discussed is PPARGC1A; the disease is metastatic melanoma.