In colon cancer, DNA damage-induced GH production was found to suppress p53-mediated apoptosis [15,16], while autocrine/paracrine GH also attenuated efficacy of irradiation and mitomycin-C or doxycycline treatment in breast and endometrial cancers by suppressing apoptosis [17,18]. The gene discussed is GH1; the disease is malignant colon neoplasm.