Although at the univariate analysis the Heterozygous for rs62625753 polymorphism showed a greater advantage in adiponectin levels increase after the HPP, the multivariate regression analysis, after correction for confounding factors, showed a significant association between Δ adiponectin and WT polymorphism, suggesting the people with severe obesity WT for rs62625753 could have a greater advantage by the HPP in respect to the Heterozygous. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.