The multivariate linear regression analysis, performed on the people with severe obesity undergone HPP, showed that the best predictor of Δ adiponectin, used as the dependent variable, was represented by the WT allele of rs62625753 c.268G>A (β = −3.290; 95% CI −5.872 −0.709. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.