ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Successively, we analysed the genotype of the ADIPOQ gene in both normal weight and people with severe obesity, finding a significant difference in the distribution of 3 polymorphisms within the population with obesity (rs17300539 c.11391G>A, rs60806105 c.11156insCA, rs1501299 c.214+62G>T).