To analyse whether the considered adiponectin polymorphisms were associated to and, therefore, could control and modify the response to the HPP in people with severe obesity, we investigated the relationship between the adiponectin polymorphisms and the changes in anthropometric and biochemical parameters after HPP (expressed as Δ value, calculated as differences between T1 and T0). Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.