To investigate the distribution of adiponectin oligomers, Western blotting was performed, in native conditions, on sera of controls and people with severe obesity: three bands corresponding to HMW (≥250 kDa), MMW (~180 kDa) and LMW (~90 kDa) oligomers were observed in both controls (Figure 1A, lanes 1–2) and people with severe obesity (Figure 1B, lanes 3–4). The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.