AKT1 and metabolic syndrome: In summary, we evaluated the anti-metabolic syndrome (MetS) activities of Fucoidan from Fucus vesiculosus (FvF) in vitro and in vivo, and the results showed that FvF with type II structure remarkably improved MetS via reactive oxygen species (ROS)-mediated regulation of c-Jun N-terminal kinase (JNK), protein kinase B (pAkt), and adenosine 5′-monophosphate-ativated protein kinase (AMPK) signaling pathway.