Although protective effects of various extracts of SC were reported on neuronal injury and memory impairment, the underlying mechanism of it still did not defined with the brain derived neurotrophic factor (BDNF) signaling, and revealed that correlation with antioxidant enzyme activation [13,14], NF-kB inhibition [15], and recovered Ach levels [10,16]. Here, BDNF is linked to memory impairment.