Other activating receptors, including NKp46, NKp30, DNAM-1, 2B4 and CD94/NKG2C, were also downregulated on NK cells from patients suffering from acute myeloid leukemia (AML), in which NK cells have also been shown to have decreased production of TNFα, IFNγ, perforin and granzymes compared to age-matched controls [81]. Here, PRF1 is linked to acute myeloid leukemia.