Previously, we and others have demonstrated that Cx43 channels accumulate at the immunological synapses during DC-T cell and DC-NK cell interactions [15,16,17] and at the NK cell-tumor cell cytotoxic immunological synapse [17,18], allowing DC-mediated T- and NK-cell activation and NK cell-mediated target tumor cell killing, respectively. Here, GJA1 is linked to neoplasm.