Similarly to the results of Cx43 localization at the cytotoxic immunological synapse and the Cx43-mediated intercellular communication, pMEL-1 CTLs but not wild-type naïve CD8+ T cells were able to induce GrzmB activity on B16F10 parental cells, which was significatively decreased when Cx43 was silenced in the target tumor cells (Figure 3B,C). The gene discussed is GJA1; the disease is neoplasm.