In concordance with the localization of Cx43 at the intercellular contact site, pMEL-1 CTLs but not wild-type naïve CD8+ T cells transferred calcein to B16F10 parental cells, and this cell coupling was partially but significatively decreased when Cx43 was silenced in the target tumor cells (Figure 2D,E). The gene discussed is CD8A; the disease is neoplasm.