Similarly to the results of Cx43 localization at the cytotoxic immunological synapse and Cx43-mediated intercellular communication, CdL43-1 CTLs were able to induce GrzmB activity and target tumor cell killing on Mel1 cells but not in K562 cells, which was significatively decreased when Cx43 channels were blocked with gap27 mimetic peptide (Figure 4E,F). The gene discussed is GJA1; the disease is neoplasm.