CD8A and neoplasm: Similarly to the results of Cx43 localization at the cytotoxic immunological synapse and the Cx43-mediated intercellular communication, pMEL-1 CTLs but not wild-type naïve CD8+ T cells were able to induce GrzmB activity on B16F10 parental cells, which was significatively decreased when Cx43 was silenced in the target tumor cells (Figure 3B,C).