In addition, Cx43 was not detected in the cell interface of cell conjugates of pMEL-1 CTLs and syngeneic bladder carcinoma MB49 cells, which do not express the MAA gp100 and therefore do not trigger the formation of functional cytotoxic immunological synapses with gp10025–33-specific CD8+ T cells (Figure 1C). The gene discussed is PMEL; the disease is urinary bladder carcinoma.