RTN4R and neoplasm: This hypothesis was further supported by the observation that the CNGRC motif had a modulatory activity on Erk activation induced by two other cytokines, IFNγ and IL12p70, whose NGR-tagged form showed an increased activity at low doses, in vivo, in murine tumor models ([52] and International Patent Application N.O. WO2008/152508, Applicant Molmed SpA).