Functions of PACS-2 unrelated to its role on MERCs also implicate it in the control of metabolism: It can block SIRT1-dependent p53 deacetylation [133], but it also allows for mTORC2 activation on MERCs via Akt [132], which are functions that could potentially explain the control of apoptosis by PACS-2 [134], as well as the protection from insulin resistance in PACS-2 knockout animals [130]. This evidence concerns the gene PACS2 and Insulin resistance.